Every Rockstar map has one region that becomes everyone's favourite by accident
Nobody planned for Blaine County to be the part of GTA V people remember. The marketing was all skyline. What people actually did was drive out past the wind farm at night and stop talking.
Red Dead had the same thing happen with the northern snow, which is a tutorial area you are supposed to leave.
So one of these six regions is going to do that and it is not going to be Vice City, because Vice City is the one they are selling. My guess is Port Gellhorn, and yes I am aware I am not an impartial observer.